1/15/2024 0 Comments Define stem cell biology![]() ![]() A clock and wavefront model for control of the number of repeated structures during animal morphogenesis. Positional information and the spatial pattern of cellular differentiation. Positional information & pattern formation. Organogenesis in a dish: modeling development and disease using organoid technologies. This study employs an in vitro model of a stem-cell-derived, developmentally-relevant, fate-patterning system and demonstrates that reaction diffusion and positional information can work in concert to give rise to emergent complexity in stem cell systems. A stepwise model of reaction-diffusion and positional-information governs self-organized human peri-gastrulation-like patterning. Positional information and reaction-diffusion: two big ideas in developmental biology combine. Dll1 + secretory progenitor cells revert to stem cells upon crypt damage. Dedifferentiation of committed epithelial cells into stem cells in vivo. Wounding induces dedifferentiation of epidermal Gata6 + cells and acquisition of stem cell properties. Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism. Digit patterning is controlled by a Bmp-Sox9 Wnt Turing network modulated by morphogen gradients. Live imaging of neurogenesis in the adult mouse hippocampus. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Self-renewing diploid Axin2 + cells fuel homeostatic renewal of the liver. ![]() Organoids: modeling development and the stem cell niche in a dish. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. An Introduction to Systems Biology: Design Principles of Biological Circuits 60, 63–64 (Chapman and Hall, 2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Type XVII collagen coordinates proliferation in the interfollicular epidermis. ![]() Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Diverse mechanisms for endogenous regeneration and repair in mammalian organs. Interleukin 22 promotes intestinal-stem-cell-mediated epithelial regeneration. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Long-term culture of genome-stable bipotent stem cells from adult human liver. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Unravelling stem cell dynamics by lineage tracing. Regeneration of the entire human epidermis using transgenic stem cells. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Hematopoietic stem cell transplantation - 50 years of evolution and future perspectives. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. ![]()
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